The aging ovary represents one of the major remaining challenges in reproductive medicine. It was chosen as the main theme of research at CHR about a decade ago. Two key events proved groundbreaking: the discovery that DHEA supplementation improves ovarian reserve and pregnancy chances in women with diminished ovarian reserve (DOR), and confirmation of the hypothesis that the FMR1 gene may be involved in regulating ovarian function. During 2011/2012, CHR completed an important second phase of this research: we started understanding how DHEA effects take place, and how wide spread effects of the FMR1 gene are, reaching far beyond our medical specialty. This second phase of our research will be presented in this year’s Research Update. With expansion of our basic science team in the laboratory, we are now entering a very important third phase, attempting to elucidate the molecular biology of ovarian aging.
- Explain the rationale for DHEA supplementation in women with diminished ovarian reserve
- Discuss the pathophysiology of premature ovarian aging (POA) in relation to androgens and follicle maturation
VIDEO: Androgens and ovulation
Recorded on: Tuesday, June 12, 2012