- Shoukhrat Mitalipov, PhD
Inherited and acquired diseases caused by mitochondrial gene (mtDNA) pauses a significant challenge, as there is currently no curative treatment for mtDNA diseases. Dr. Mitalipov’s presentation will focus on novel reproductive approaches to prevent transmission of mtDNA mutations from parents to children. mtDNA is maternally transmitted through the oocyte. Mutated mtDNA in a patient’s oocyte can be replaced with healthy genome from a donor oocyte, and resulting oocyte can be fertilized and transplanted into the patient’s uterus.
- 1. Explain the genetics of mtDNA and the mechanisms of transmission to next generation
- 2. List major inherited diseases caused by mtDNA mutations
- 3. Describe novel intervention approaches to prevent transmission of mtDNA mutations from a mother to a child
VIDEO: Mitochondrial genome during reproduction, development and aging
Recorded on: Tuesday, March 13, 2012