Lectures

Mitochondrial genome during reproduction, development and aging

Lecture Type: Grandrounds

Mitochondrial genome during reproduction, development and aging

Shoukhrat Mitalipov, PhD

Senior Scientist, Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Stem Cell Center and Departments of Obstetrics & Gynecology and Molecular & Medical Genetics

Dr. Mitalipov is a prominent researcher in the field of primate mitochondrial functions. He earned his PhD degree in Developmental & Stem Cell Biology at the Research Center for Medical Genetics in Moscow, Russia. He came to Utah State University in 1995 to conduct his postdoctoral research in stem cell and developmental biology. Dr. Mitalipov moved to the Oregon National Primate Research Center in 1998, and is now Senior Scientist at the ONPRC. Dr. Mitalipov’s recent research into the novel gene therapy to address inheritance of mtDNA mutations has drawn considerable attention, as the technique of mitochondrial genome replacement in primate oocytes by spindle-chromosomal complex transfer has been successfully performed in primate oocytes, resulting in healthy offspring.

Invited Speakers

  • Shoukhrat Mitalipov, PhD

Context

Inherited and acquired diseases caused by mitochondrial gene (mtDNA) pauses a significant challenge, as there is currently no curative treatment for mtDNA diseases. Dr. Mitalipov’s presentation will focus on novel reproductive approaches to prevent transmission of mtDNA mutations from parents to children. mtDNA is maternally transmitted through the oocyte. Mutated mtDNA in a patient’s oocyte can be replaced with healthy genome from a donor oocyte, and resulting oocyte can be fertilized and transplanted into the patient’s uterus.

Objetives

  • 1. Explain the genetics of mtDNA and the mechanisms of transmission to next generation
  • 2. List major inherited diseases caused by mtDNA mutations
  • 3. Describe novel intervention approaches to prevent transmission of mtDNA mutations from a mother to a child

VIDEO: Mitochondrial genome during reproduction, development and aging


Recorded on: Tuesday, March 13, 2012

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