Mitochondrial function is integral to both somatic cell and gamete aging. Novel therapies aimed at the mitochondria may help to delay or reverse reproductive aging and transmission of mitochondrial diseases. One of the most promising therapies for female fertility is CoQ10 supplementation. CoQ10 may improve female fertility by supporting energy metabolism within the oocytes. In this lecture, a review of mitochondrial genetics and mechanisms of female reproductive aging will be supplemented with a review of past and future treatments involving oocyte mitochondria. In addition, recent human and animal data on which current understanding of oocyte biology will be reviewed.
- Describe basic principles of mitochondrial genetics
- Explain role of mitochondrial number and function in the aging process
- List past and emerging techniques to prevent genetic transmissions of mitochondrial diseases
VIDEO: Mitochondrial role in female reproductive aging
Recorded on: Tuesday, November 20, 2012