- Gerald P Schatten, PhD
Idiopathic infertility, both male and female, are likely the result of defects in the organelles and components which are essential for successful fertilization but are transmitted as extra-nuclear elements. Diagnosis of these types of cytoplasmic and epigenetic anomalies is predicted to help with improved ART success rates, since some patient couples may find that they are unlikely to enjoy benefits without donor gametes. Further, the missing components may be introduced and finally understanding of these critical elements vital for fertilization and the onset of development may lead to improved contraceptive strategies. Male factor infertility may result in the embryo failing to divide even after it is scored as a successful fertilization. Physicians and their laboratory colleagues will be encountered to expand their diagnostic horizons regarding the reasons why development arrests.
- Discuss factors within the oocyte which might cause fertilization to fail and development to arrest.
- Articulate how sperm with normal motility may not fulfill its obligations during fertilization and how even ICSI may be ineffective in this form of male factor infertility.
- Explain imprintopathies and centrosomopathies are novel causes of infertility that may bring relief to patient couples currently suffering from intractable infertility.
VIDEO: The “Center for Human Reproduction”: The essential roles of sperm centrosome during fertilization, infertility and ART
Recorded on: Tuesday, September 11, 2012